pentobarbital will lower the level or impact of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If not able to steer clear of coadministration of stiripentol with potent CYP3A4 inducers, enhance stiripentol dose.pentobarbital will reduce the level or effect of ibuprofen by impacting hepatic enzym